ROBO4
Synonyms
Magic roundabout, ECSM4, Roundabout Guidance Receptor 4, Roundabout, Axon Guidance Receptor, Homolog 4, Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila), MRB, FLJ20798, AOVD3, Roundabout Homolog 4, Magic Roundabout, Roundabout Homolog 4 (Drosophila)
Description
Roundabout homolog 4 (ROBO4) is the receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. It may mediate the inhibition of primary endothelial cell migration by Slit proteins and be involved in the maintenance of endothelial barrier organization and function .
KO Status
F1 (+/-)
Drug Information
Drug Name
Code
Phase
Company
Indications
Clinical Trials
anti-ILT3 CAR-T（Carbiogene）
Nidanilimab
CAN-04
Phase 2 Clinical
Lund University Foundation
Squamous Cell Carcinoma of Head and Neck, Pancreatic Neoplasms, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Breast Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal, Carcinoma, Non-Small-Cell Lung, Melanoma
HLX-71
HLX-71
Phase 1 Clinical
Hengenix Biotech Inc
Coronavirus Disease 2019 (COVID-19)
BI-1910
BI-1910
Preclinical
Bioinvent International
Solid tumours
IPR-1110
IPR 1110
Preclinical
Neoplasms
MNPR-101
huATN-658
Preclinical
Monopar Therapeutics Inc
Neoplasms
References
Title
Authors
Source
Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis
Huminiecki L., Gorn M., Suchting S., Poulsom R., Bicknell R.,
Genomics 79:547-552(2002)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Gray A.M.,
Genome Res. 13:2265-2270(2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,
Nat. Genet. 36:40-45(2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
The MGC Project Team,
Genome Res. 14:2121-2127(2004)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.,
J. Proteome Res. 4:2070-2080(2005)
A strategy for precise and large scale identification of core fucosylated glycoproteins
Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.,
Mol. Cell. Proteomics 8:913-923(2009)
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.,
J. Proteomics 96:253-262(2014)
ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm
Baylor-Hopkins Center for Mendelian Genomics, MIBAVA Leducq Consortium, Gould R.A., Aziz H., Woods C.E., Seman-Senderos M.A., Sparks E., Preuss C., Wuennemann F., Bedja D., Moats C.R., McClymont S.A., Rose R., Sobreira N., Ling H., MacCarrick G., Kumar A.A., Luyckx I., Cannaerts E., Verstraeten A., Dietz H.C.,
Nat. Genet. 51:42-50(2019)