ROBO4

Synonyms

Magic roundabout, ECSM4, Roundabout Guidance Receptor 4, Roundabout, Axon Guidance Receptor, Homolog 4, Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila), MRB, FLJ20798, AOVD3, Roundabout Homolog 4, Magic Roundabout, Roundabout Homolog 4 (Drosophila),

Description

Roundabout homolog 4 (ROBO4) is the receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. It may mediate the inhibition of primary endothelial cell migration by Slit proteins and be involved in the maintenance of endothelial barrier organization and function .

KO Status

F1 (+/-)

Drug Information

Launched drugs: 0
Drugs in clinical trials: 0

Drug Name

Code

Phase

Company

Indications

Clinical Trials

BI-1910

BI-1910

Preclinical

Bioinvent International

Solid tumours

IPR-1110

IPR 1110

Preclinical

Neoplasms

MNPR-101

huATN-658

Preclinical

Monopar Therapeutics Inc

Neoplasms

Nidanilimab

CAN-04

Phase 2 Clinical

Lund University Foundation

Squamous Cell Carcinoma of Head and Neck, Pancreatic Neoplasms, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Breast Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal, Carcinoma, Non-Small-Cell Lung, Melanoma

HLX-71

HLX-71

Phase 1 Clinical

Hengenix Biotech Inc

Coronavirus Disease 2019 (COVID-19)