Magic roundabout, ECSM4, Roundabout Guidance Receptor 4, Roundabout, Axon Guidance Receptor, Homolog 4, Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila), MRB, FLJ20798, AOVD3, Roundabout Homolog 4, Magic Roundabout, Roundabout Homolog 4 (Drosophila)


Roundabout homolog 4 (ROBO4) is the receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. It may mediate the inhibition of primary endothelial cell migration by Slit proteins and be involved in the maintenance of endothelial barrier organization and function .

KO Status

F1 (+/-)

Drug Information

Drug Name





Clinical Trials

anti-ILT3 CAR-T(Carbiogene)



Phase 2 Clinical

Lund University Foundation

Squamous Cell Carcinoma of Head and Neck, Pancreatic Neoplasms, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Breast Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal, Carcinoma, Non-Small-Cell Lung, Melanoma



Phase 1 Clinical

Hengenix Biotech Inc

Coronavirus Disease 2019 (COVID-19)




Bioinvent International

Solid tumours


IPR 1110






Monopar Therapeutics Inc






Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis

Huminiecki L., Gorn M., Suchting S., Poulsom R., Bicknell R.,

Genomics 79:547-552(2002)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment

Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Gray A.M.,

Genome Res. 13:2265-2270(2003)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry

Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.,

J. Proteome Res. 4:2070-2080(2005)

A strategy for precise and large scale identification of core fucosylated glycoproteins

Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.,

Mol. Cell. Proteomics 8:913-923(2009)

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome

Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.,

J. Proteomics 96:253-262(2014)

ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm

Baylor-Hopkins Center for Mendelian Genomics, MIBAVA Leducq Consortium, Gould R.A., Aziz H., Woods C.E., Seman-Senderos M.A., Sparks E., Preuss C., Wuennemann F., Bedja D., Moats C.R., McClymont S.A., Rose R., Sobreira N., Ling H., MacCarrick G., Kumar A.A., Luyckx I., Cannaerts E., Verstraeten A., Dietz H.C.,

Nat. Genet. 51:42-50(2019)