Sclerostin

Synonyms

Sclerostin, UNQ2976/PRO7455/PRO7476, SOST, Sclerosteosis, DAND6, SOST1, VBCH, CDD,

Description

Sclerostin is the negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

KO Status

F1 (+/-)

Drug Information

Launched drug: 1
Drugs in clinical trials: 3
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Romosozumab

AMG-785, CDP-7851

Approved

Amgen Inc, Ucb Sa

Osteoporosis, Bone Diseases, Metabolic, Osteoporosis, Postmenopausal, Osteogenesis Imperfecta

Blosozumab

LY-2541546

Phase 2 Clinical

Eli Lilly And Company

Osteoporosis, Osteoporosis, Postmenopausal

Setrusumab

NOV-3, BPS-804, MOR-05813

Phase 2 Clinical

Morphosys, Novartis Pharma Ag

Osteoporosis, Bone Diseases, Metabolic, Hypophosphatasia, Osteogenesis Imperfecta, Renal Insufficiency, Chronic

SHR-1222

SHR-1222

Phase 1 Clinical

Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd, Suzhou Suncadia Biopharmaceuticals Co Ltd

Osteoporosis, Osteoporosis, Postmenopausal

AMG-167

AMG-167

Pending

Amgen Inc

Bone Diseases, Metabolic, Osteoporosis