Sclerostin
Synonyms
Sclerostin, UNQ2976/PRO7455/PRO7476, SOST, Sclerosteosis, DAND6, SOST1, VBCH, CDD,Description
Sclerostin is the negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
KO Status
F1 (+/-)
Drug Information
Launched drugs: 3
Drug in clinical trials: 1
Latest Research Phase:Approved
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Romosozumab
AMG-785, CDP-7851
Approved
Amgen Inc, Ucb Sa
Osteoporosis, Bone Diseases, Metabolic, Osteoporosis, Postmenopausal, Osteogenesis Imperfecta
Blosozumab
LY-2541546
Phase 2 Clinical
Eli Lilly And Company
Osteoporosis, Osteoporosis, Postmenopausal
Setrusumab
NOV-3, BPS-804, MOR-05813
Phase 2 Clinical
Morphosys, Novartis Pharma Ag
Osteoporosis, Bone Diseases, Metabolic, Hypophosphatasia, Osteogenesis Imperfecta, Renal Insufficiency, Chronic
SHR-1222
SHR-1222
Phase 1 Clinical
Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd, Suzhou Suncadia Biopharmaceuticals Co Ltd
Osteoporosis, Osteoporosis, Postmenopausal
AMG-167
AMG-167
Pending
Amgen Inc
Bone Diseases, Metabolic, Osteoporosis