TEM1

Synonyms

Tumor endothelial marker 1, Endosialin, CD164L1, CD248, CD248 Molecule, CD248 Molecule, Endosialin, CD248 Antigen, Endosialin, CD164 Sialomucin-Like 1, TEM1, 2610111G01Rik, CD248 Antigen

Description

Endosialin may play a role in tumor angiogenesis.Endosialin is a protein that in humans is encoded by the CD248 gene.Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion processes but also in host defence. This family comprise three other members, CLEC14A, CD93 and Thrombomodulin the latter of which are better characterized.The function of endosialin remains elusive, but its expression has been associated with angiogenesis in the embryo and uterus and in tumor development and growth.

KO Status

RenMab: F2 (-/-)

Drug Information

Drug in clinical trials: 1
Latest Research Phase: Phase 2 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Ontuxizumab (Ontecizumab)

M-4, ES-1, MORAb-004

Phase 2 Clinical

Ludwig Institute For Cancer Research, Morphotek

Solid tumours, Lymphoma, T-Cell, Peripheral, Lymphoma, B-Cell, Lymphoma, B-Cell, Marginal Zone, Leukemia, Hairy Cell, Lymphomatoid Granulomatosis, Lymphoma, Large-Cell, Immunoblastic, Hodgkin Disease, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell, Lymphoma, Follicular, Sarcoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Sezary Syndrome, Colorectal Neoplasms, Lymphoproliferative Disorders, Lymphoma, T-Cell, Lymphoma, Large-Cell, Anaplastic, Lymphoma, T-Cell, Cutaneous, Waldenstrom Macroglobulinemia, Lymphoma, Neoplasms, Gonadal Tissue, Burkitt Lymphoma, Intraocular Lymphoma, Lymphoma, Non-Hodgkin, Mycosis Fungoides, Leukemia, T-Cell, Melanoma, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Large Granular Lymphocytic

References


Title

Authors

Source

Genes expressed in human tumor endothelium

St Croix B., Rago C., Velculescu V.E., Traverso G., Romans K.E., Montgomery E., Lal A., Riggins G.J., Lengauer C., Vogelstein B., Kinzler K.W.,

Science 289:1197-1202(2000)

Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium

Christian S., Ahorn H., Koehler A., Eisenhaber F., Rodi H.P., Garin-Chesa P., Park J.E., Rettig W.J., Lenter M.C.,

J. Biol. Chem. 276:7408-7414(2001)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer

Rettig W.J., Garin-Chesa P., Healey J.H., Su S.L., Jaffe E.A., Old L.J.,

Proc. Natl. Acad. Sci. U.S.A. 89:10832-10836(1992)

Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin

Dolznig H., Schweifer N., Puri C., Kraut N., Rettig W.J., Kerjaschki D., Garin-Chesa P.,

Cancer Immun. 5:10-10(2005)

Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium

MacFadyen J.R., Haworth O., Roberston D., Hardie D., Webster M.T., Morris H.R., Panico M., Sutton-Smith M., Dell A., van der Geer P., Wienke D., Buckley C.D., Isacke C.M.,

FEBS Lett. 579:2569-2575(2005)

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome

Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.,

J. Proteomics 96:253-262(2014)

The consensus coding sequences of human breast and colorectal cancers

Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Velculescu V.E.,

Science 314:268-274(2006)