TGM2, Transglutaminase 2 (C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase), EC, C Polypeptide, Protein-Glutamine-Gamma-Glutamyltransferase, EC:, TG(C), Tissue Transglutaminase, TGase-2, Protein-Glutamine Gamma-Glutamyltransferase 2, Transglutaminase-2, TGC, TGase H, TGase C, Transglutaminase H, Transglutaminase 2, Transglutaminase C


Tissue transglutaminase (abbreviated as tTG or TG2) is a 78-kDa, calcium-dependent enzyme (EC of the protein-glutamine γ-glutamyltransferases family (or simply transglutaminase family). Like other transglutaminases, it crosslinks proteins between an ε-amino group of a lysine residue and a γ-carboxamide group of glutamine residue, creating an inter- or intramolecular bond that is highly resistant to proteolysis (protein degradation). Aside from its crosslinking function, tTG catalyzes other types of reactions including deamidation, GTP-binding/hydrolyzing, and isopeptidase activities.Unlike other members of the transglutaminase family, tTG can be found both in the intracellular and the extracellular spaces of various types of tissues and is found in many different organs including the heart, the liver, and the small intestine. Intracellular tTG is abundant in the cytosol but smaller amounts can also be found in the nucleus and the mitochondria.Intracellular tTG is thought to play an important role in apoptosis.In the extracellular space, tTG binds to proteins of the extracellular matrix (ECM).binding particularly tightly to fibronectin.Extracellular tTG has been linked to cell adhesion, ECM stabilization, wound healing, receptor signaling, cellular proliferation, and cellular motility.tTG is particularly notable for being the autoantigen in celiac disease, a lifelong illness in which the consumption of dietary gluten causes a pathological immune response resulting in the inflammation of the small intestine and subsequent villous atrophy.It has also been implicated in the pathophysiology of many other diseases, including such as many different cancers and neurogenerative diseases

KO Status

RenMab: F1 (+/-)

Drug Information

Drugs in clinical trials: 2
Latest Research Phase: Phase 2 Clinical

Drug Name





Clinical Trials


ZED-101, ZED-1227

Phase 2 Clinical


Celiac Disease



Phase 2 Clinical

Ucb Sa

Autoimmune Diseases

Putrescine dihydrochloride



Cicatrix, Hypertrophic





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Nat. Genet. 36:40-45(2004)

The DNA sequence and comparative analysis of human chromosome 20

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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

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Genome Res. 14:2121-2127(2004)

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs

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BMC Syst. Biol. 5:17-17(2011)

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A third human tissue transglutaminase homologue as a result of alternative gene transcripts

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N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB

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J. Proteomics 96:253-262(2014)