TLR3

Synonyms

CD283, TLR3, Toll Like Receptor 3, Toll-Like Receptor 3, CD283 Antigen, IIAE2,

Description

Toll like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene. TLR3 is the key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. TLR3 acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.

KO Status

F0

Drug Information

Launched drugs: 9
Drug in clinical trials: 1
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Riboxxim

RGC-1, RGC-L1, RGC-L2, RGIC-1

Preclinical

Riboxx Pharmaceuticals

Virus Diseases

Rintatolimod

Approved

Hemispherx Biopharma

HIV Infections, Influenza, Human, Fatigue Syndrome, Chronic, HIV Seropositivity

TR-987

Z-101, GLYC-101, MG-3601

Phase 2 Clinical

Kazia Therapeutics

Wounds and Injuries, Varicose Ulcer

CNTO-3157

PRV-300, CNTO-3157, JNJ-42915925

Phase 2 Clinical

Centocor Ortho Biotech, Morphosys Ag

Asthma, Colitis, Ulcerative

H1N1 seasonal influenza virus vaccine (Vaxart)

VXA-A1.1

Phase 2 Clinical

Vaxart

Influenza A virus infections, Influenza, Human

Poly ICLC (Oncovir)

Phase 2 Clinical

National Institutes Of Health, Yamasa Corp

HIV Infections, Smallpox, Lymphoma, B-Cell, Liver Neoplasms, Ovarian Neoplasms, Coronavirus Disease 2019 (COVID-19), Lymphoma, Large B-Cell, Diffuse, Glioblastoma, Pancreatic Neoplasms, Cytomegalovirus Infections, Mesothelioma, Influenza, Human, Prostatic Neoplasms, Colorectal Neoplasms, Uterine Cervical Dysplasia, Glioma, Melanoma

PGV-001

PGV-001

Phase 1 Clinical

Genentech Inc, Icahn School Of Medicine At Mount Sinai

Neoplasms

Hepatitis B vaccine (Yisheng Biopharma)

Phase 1 Clinical

Yisheng Biopharma

Hepatitis B

Monovalent norovirus Vaccine (Vaxart)

VXA-G1-1-NN, VXA-G1.1-NN

Phase 1 Clinical

Vaxart

Caliciviridae Infections

CNTO-5

CNTO-5

Phase 1 Clinical

Morphosys Ag

Inflammation

Respiratory syncytial virus vaccine oral (Vaxart)

VXA-RSV-f

Phase 1 Clinical

Vaxart

Respiratory Syncytial Virus Infections

H5N1 avian influenza virus vaccine (Vaxart)

ND-1, ND-1.1

Pending

Vaxart

Influenza in Birds

VXA-BYW-10

VXA-BYW-10

Pending

Vaxart

Influenza B virus infection

MCT-475

MCT-475, MCT-485

Pending

Multicell Technologies

Hepatitis, Chronic, Liver Neoplasms

RNA-144101

RNA-144101

Discontinued

University Of Kentucky

Macular Degeneration

Verpasep caltespen

Discontinued

Nventa Biopharmaceuticals Co

Papillomavirus Infections, Respiratory papillomatosis, Cervical Intraepithelial Neoplasia, Uterine Cervical Dysplasia, Papilloma, Uterine Cervical Neoplasms