TNF

Synonyms

Tumor Necrosis Factor (TNF Superfamily, Member 2), Tumor Necrosis Factor Ligand 1F, Tumor Necrosis Factor-Alpha, TNF Superfamily, Member 2, TNF, Macrophage-Derived, TNF, Monocyte-Derived, APC1 Protein, TNLG1F, DIF, ICD1, Tumor necrosis factor, NTF, TNF-a, TNF-alpha, ICD2, N-terminal fragment, TNF, Tumor necrosis factor ligand superfamily member 2, Cachectin, TNFSF2, TNFA,

Description

Tumor necrosis factor α is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as T helper cells, natural killer cells, neutrophils, mast cells, eosinophils, and neurons.TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective . Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line . Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 .The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

KO Status

F0

Drug Information

Launched drugs: 63
Drugs in clinical trials: 46
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Adalimumab biosimilar (Sandoz)

GP-2017

Approved

Sandoz

Arthritis, Rheumatoid, Spondylitis, Ankylosing, Psoriasis, Arthritis, Psoriatic, Colitis, Ulcerative, Hidradenitis Suppurativa, Uveitis, Crohn Disease

Infliximab (Hisun Biopharmaceutical)

IND

Hisun Biological Pharmaceutical Co Ltd

Adalimumab biosimilar (Jiangsu Zhonghe)

UBP-1211

NDA/BLA

Shanghai Junshi Biosciences Co Ltd, Jiangsu Zhonghe Pharmaceutical Technology Co Ltd

Arthritis, Rheumatoid

Etanercept biosimilar (Qilu Pharmaceutical)

QL-0902

NDA/BLA

Qilu Pharmaceutical Co Ltd

Arthritis, Rheumatoid, Spondylitis, Ankylosing

Adalimumab biosimilar (Fujifilm Kyowa Kirin Biologics/Mylan)

FKB-327

Approved

Fujifilm Kyowa Kirin Biologics

Arthritis, Rheumatoid, Spondylitis, Ankylosing, Colitis, Ulcerative, Arthritis, Psoriatic, Uveitis, Hidradenitis Suppurativa, Crohn Disease

Adalimumab

D2E7, ABT-D2E7, LU-200134

Approved

Abbvie Inc

Pyoderma Gangrenosum, Arthritis, Rheumatoid, Spondylitis, Ankylosing, Arthritis, Juvenile, Psoriasis, Asthma, Colitis, Ulcerative, Arthritis, Psoriatic, Osteoarthritis, Knee, Uveitis, Arthritis, Hidradenitis Suppurativa, Crohn Disease, Plaque psoriasis

Adalimumab biosimilar (Reliance Life Sciences)

R-TPR-021

Approved

Reliance Life Sciences

Spondylitis, Ankylosing, Arthritis, Rheumatoid, Psoriasis, Arthritis, Psoriatic, Colitis, Ulcerative

Adalimumab biosimilar (Samsung Bioepis)

SB-5

Approved

Samsung Bioepis

Spondylitis, Ankylosing, Arthritis, Rheumatoid, Arthritis, Juvenile, Psoriasis, Arthritis, Psoriatic, Colitis, Ulcerative, Hidradenitis Suppurativa, Uveitis, Crohn Disease

Infliximab biosimilar (Nichiiko Pharmaceutical/Aprogen)

GS-071, NI-071

Approved

Nichi-Iko Pharmaceutical, Aprogen

Arthritis, Rheumatoid, Psoriasis, Arthritis, Psoriatic, Colitis, Ulcerative, Crohn Disease

Infliximab biosimilar (Bionovis/The Instituto Vital Brazil)

Approved

Bionovis, The Instituto Vital Brazil

Arthritis, Rheumatoid, Spondylitis, Ankylosing, Psoriasis, Arthritis, Psoriatic, Colitis, Ulcerative, Crohn Disease

Pentoxifylline

BL-191, EHT-201, EHT-0201

Approved

U.S. Pharmaceuticals Holdings I

Hepatitis, Chronic, Peripheral Vascular Diseases, Hepatitis, Kidney Failure, Chronic, Behcet Syndrome

Etanercept biosimilar (Shanghai Celgen)

Approved

Shanghai Celgen Bio-Pharmaceutical Co Ltd

Psoriasis

Etanercept biosimilar (Hanwha Chemical)

HD-203, MK-8953

Approved

Hanwha Chemical

Spondylitis, Ankylosing, Arthritis, Rheumatoid, Psoriasis, Arthritis, Psoriatic

Infliximab (dyyb)

CT-P13

Approved

Celltrion

Spondylitis, Ankylosing, Arthritis, Rheumatoid, Psoriasis, Arthritis, Psoriatic, Colitis, Ulcerative, Urologic Neoplasms, Crohn Disease

Infliximab biosimilar (Shanghai Biomabs)

CMAB-008, STI-002

NDA/BLA

Shanghai Biomabs Pharmaceuticals Co Ltd

Arthritis, Rheumatoid

Pomalidomide

CDC-394, CC-4047, IMiD-1, IMID-4047

Approved

Celgene Corp

Medulloblastoma, Lymphoma, B-Cell, Bone Marrow Neoplasms, Hodgkin Disease, Scleroderma, Systemic, Lymphoma, Large B-Cell, Diffuse, Multiple Myeloma, Central Nervous System Neoplasms, Lung Diseases, Interstitial, Prostatic Neoplasms, Sarcoma, Lymphoma, Follicular, Primary Myelofibrosis, Lymphoma, Non-Hodgkin, Carcinoma, Small Cell, Neoplasm Metastasis, Sarcoma, Kaposi, Anemia, Sickle Cell, Leukemia, Lymphocytic, Chronic, B-Cell

Recombinant chimeric anti-TNFα antibody (Hisun Pharma)

HS-626

NDA/BLA

Zhejiang Hisun Pharmaceutical Co Ltd

Psoriasis

Etanercept biosimilar (AryoGen Biopharma)

Approved

Aryogen Biopharma

Spondylitis, Ankylosing, Arthritis, Rheumatoid, Arthritis, Juvenile, Psoriasis, Arthritis, Psoriatic

Adalimumab-adbm

BI-695501

Approved

C.H. Boehringer Sohn Ag & Co. Kg

Spondylitis, Ankylosing, Arthritis, Rheumatoid, Arthritis, Juvenile, Psoriasis, Colitis, Ulcerative, Arthritis, Psoriatic, Uveitis, Hidradenitis Suppurativa, Crohn Disease

Etanercept biosimilar (Shanghai Fudan-Zhangjiang Bio-Pharmaceutical)

NDA/BLA

Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd

Arthritis, Rheumatoid