TNFSF15

Synonyms

TNLG1B, Vascular Endothelial Cell Growth Inhibitor, VEGI192A, Tumor Necrosis Factor Ligand Superfamily Member 15, Vascular Endothelial Growth Inhibitor-192A, VEGI, TNF Ligand-Related Molecule 1, TL1, Tumor Necrosis Factor Superfamily Member 15, Tumor Necrosis Factor Ligand 1B, TL1A, TNF Superfamily Member 15, TNFSF15, TNF Superfamily Ligand TL1A, Tumor Necrosis Factor (Ligand) Superfamily, Member 15, MGC129934, MGC129935

Description

Tumor necrosis factor superfamily member 15 (TNFSF15) is also known Vascular endothelial growth inhibitor (VEGI) and TNF-like ligand 1A (TL1A). TNFSF15 is the receptor for TNFRSF25 and TNFRSF6B. It mediates activation of NF-kappa-B, inhibits vascular endothelial growth and angiogenesis (in vitro) and promotes activation of caspases and apoptosis.

KO Status

RenMab: F0

Drug Information

Drug in clinical trials: 1
Latest Research Phase: Phase 2 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

PF-06480605

PF-06480605

Phase 2 Clinical

Pfizer Pharmaceuticals Ltd (China)

Colitis, Ulcerative, Crohn Disease

PRA-023

PRA-023

Phase 1 Clinical

Prometheus Biosciences Inc

Inflammatory Bowel Diseases

References


Title

Authors

Source

DNA sequence and analysis of human chromosome 9

Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L., Dunham I.,

Nature 429:369-374(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells

Tan K.B., Harrop J., Reddy M., Young P., Terrett J., Emery J., Moore G., Truneh A.,

Gene 204:35-46(1997)

VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth

Haridas V., Shrivastava A., Su J., Yu G.-L., Ni J., Liu D., Chen S.-F., Ni Y., Ruben S.M., Gentz R., Aggarwal B.B.,

Oncogene 18:6496-6504(1999)

X-ray crystal structure of TNF ligand family member TL1A at 2.1A

Jin T., Guo F., Kim S., Howard A., Zhang Y.-Z.,

Biochem. Biophys. Res. Commun. 364:1-6(2007)

Decoy strategies: the structure of TL1A:DcR3 complex

Zhan C., Patskovsky Y., Yan Q., Li Z., Ramagopal U., Cheng H., Brenowitz M., Hui X., Nathenson S.G., Almo S.C.,

Structure 19:162-171(2011)

VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo

Zhai Y., Ni J., Jiang G.-W., Lu J., Xing L., Lincoln C., Carter K.C., Janat F., Kozak D., Xu S., Rojas L., Aggarwal B.B., Ruben S., Li L.-Y., Gentz R., Yu G.-L.,

FASEB J. 13:181-189(1999)

A novel secreted splice variant of vascular endothelial cell growth inhibitor

Chew L.-J., Pan H., Yu J., Tian S., Huang W.-Q., Zhang J.Y., Pang S., Li L.-Y.,

FASEB J. 16:742-744(2002)

TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator

Migone T.-S., Zhang J., Luo X., Zhuang L., Chen C., Hu B., Hong J.S., Perry J.W., Chen S.-F., Zhou J.X.H., Cho Y.H., Ullrich S., Kanakaraj P., Carrell J., Boyd E., Olsen H.S., Hu G., Pukac L., Wei P.,

Immunity 16:479-492(2002)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)