TNFSF15
Synonyms
VEGI192A, Vascular Endothelial Cell Growth Inhibitor, TNF Superfamily Ligand TL1A, TNFSF15, Tumor Necrosis Factor (Ligand) Superfamily, Member 15, Vascular Endothelial Growth Inhibitor-192A, VEGI, TL1A, Tumor Necrosis Factor Ligand 1B, TNLG1B, TNF Superfamily Member 15, Tumor Necrosis Factor Superfamily Member 15, TL1, TNF Ligand-Related Molecule 1, Tumor Necrosis Factor Ligand Superfamily Member 15, MGC129934, MGC129935
Description
Tumor necrosis factor superfamily member 15 (TNFSF15) is also known Vascular endothelial growth inhibitor (VEGI) and TNF-like ligand 1A (TL1A). TNFSF15 is the receptor for TNFRSF25 and TNFRSF6B. It mediates activation of NF-kappa-B, inhibits vascular endothelial growth and angiogenesis (in vitro) and promotes activation of caspases and apoptosis.
KO Status
RenMab: F0
Drug Information
Drugs in clinical trials: 2
Latest Research Phase: Phase 2 Clinical
Drug Name
Code
Phase
Company
Indications
Clinical Trials
PF-06480605
PF-06480605
Phase 2 Clinical
Pfizer Pharmaceuticals Ltd (China)
Colitis, Ulcerative, Crohn Disease
PRA-023
PRA-023
Phase 2 Clinical
Prometheus Biosciences Inc
Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
References
Title
Authors
Source
DNA sequence and analysis of human chromosome 9
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L., Dunham I.,
Nature 429:369-374(2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
The MGC Project Team,
Genome Res. 14:2121-2127(2004)
Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells
Tan K.B., Harrop J., Reddy M., Young P., Terrett J., Emery J., Moore G., Truneh A.,
Gene 204:35-46(1997)
VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth
Haridas V., Shrivastava A., Su J., Yu G.-L., Ni J., Liu D., Chen S.-F., Ni Y., Ruben S.M., Gentz R., Aggarwal B.B.,
Oncogene 18:6496-6504(1999)
X-ray crystal structure of TNF ligand family member TL1A at 2.1A
Jin T., Guo F., Kim S., Howard A., Zhang Y.-Z.,
Biochem. Biophys. Res. Commun. 364:1-6(2007)
Decoy strategies: the structure of TL1A:DcR3 complex
Zhan C., Patskovsky Y., Yan Q., Li Z., Ramagopal U., Cheng H., Brenowitz M., Hui X., Nathenson S.G., Almo S.C.,
Structure 19:162-171(2011)
VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo
Zhai Y., Ni J., Jiang G.-W., Lu J., Xing L., Lincoln C., Carter K.C., Janat F., Kozak D., Xu S., Rojas L., Aggarwal B.B., Ruben S., Li L.-Y., Gentz R., Yu G.-L.,
FASEB J. 13:181-189(1999)
A novel secreted splice variant of vascular endothelial cell growth inhibitor
Chew L.-J., Pan H., Yu J., Tian S., Huang W.-Q., Zhang J.Y., Pang S., Li L.-Y.,
FASEB J. 16:742-744(2002)
TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator
Migone T.-S., Zhang J., Luo X., Zhuang L., Chen C., Hu B., Hong J.S., Perry J.W., Chen S.-F., Zhou J.X.H., Cho Y.H., Ullrich S., Kanakaraj P., Carrell J., Boyd E., Olsen H.S., Hu G., Pukac L., Wei P.,
Immunity 16:479-492(2002)
Complete sequencing and characterization of 21,243 full-length human cDNAs
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,
Nat. Genet. 36:40-45(2004)