UPA

Synonyms

PLAU, uPA, Plasminogen Activator, Urokinase, Urokinase-Type Plasminogen Activator, Plasminogen Activator, Urinary, BDPLT5, U-PA, ATF, QPD, URK, EC:3.4.21.73, EC 3.4.21, U-Plasminogen Activator, EC 3.4.21.73,

Description

Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. Urokinase was originally isolated from human urine, and it is also present in the blood and in the extracellular matrix of many tissues. The primary physiological substrate of this enzyme is plasminogen, which is an inactive form (zymogen) of the serine protease plasmin. Activation of plasmin triggers a proteolytic cascade that, depending on the physiological environment, participates in thrombolysis or extracellular matrix degradation. This cascade had been involved in vascular diseases and cancer progression.

KO Status

F0

Drug Information

Launched drugs: 5
Drugs in clinical trials: 2
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

IPR-1110

IPR 1110

Preclinical

Neoplasms

Nasaruplase

GE-0943

Approved

Mitsubishi Pharma

Myocardial Infarction, Venous Thrombosis

Urokinase biosimilar (Bharat Serums & Vaccines)

U-FRAG

Approved

Bharat Serums And Vaccines

Pulmonary Embolism

Upamostat Hydrogen Sulphate

LH-011, WX-671

Phase 2 Clinical

Wilex

Pancreatic Neoplasms, Breast Neoplasms, Colorectal Neoplasms

tPA/HisproUK (Thrombolytic Science)

TS-01

Phase 2 Clinical

Thrombolytic Science

Stroke

Gallium-68 NOTA AE105 (Curasight)

CS-001, 68Ga-NOTA-AE105

Phase 2 Clinical

Curasight

Head and Neck Neoplasms, Glioblastoma, Neuroendocrine Tumors, Mesothelioma, Urinary Bladder Neoplasms, Breast Neoplasms, Prostatic Neoplasms, Oropharyngeal Neoplasms, Genital Neoplasms, Female, Carcinoma, Non-Small-Cell Lung

Angstrom6

A6

Phase 2 Clinical

Angstrom

Ovarian Neoplasms, Peritoneal Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell

Recombinant human annexin 5 protein (Yabao Pharmaceuticals)

SY-005

Phase 1 Clinical

Lawson Health Research Institute, Yabao Pharmaceutical Group Co Ltd

Sepsis

Recombinant staphylokinase-hirudin fusion protein

Pending

Institute Of Radiological Medicine, Chinese Academy Of Military Medical Sciences, Humanwell Healthcare (Group) Co Ltd

Thromboembolism

Saruplase

CG-4509

Discontinued

Grunenthal, Genentech Inc

Myocardial Infarction

UK-356202

UK-356202

Discontinued

Pfizer Inc

Vascular Diseases, Skin Ulcer, Neoplasm Metastasis

WX-UK1

WX-UK1

Discontinued

Wilex

Neoplasms

KK-220

KK-220

Discontinued

Kowa

Eye Diseases