VAP-1

Synonyms

SSAO, AOC3, Amine Oxidase, Copper Containing 3, Semicarbazide-Sensitive Amine Oxidase, Copper Amine Oxidase, Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1), Placenta Copper Monamine Oxidase, VAP-1, Membrane primary amine oxidase, VAP1, HPAO, EC 1.4.3, Vascular adhesion protein 1, EC 1.4.3.21, Amine Oxidase Copper Containing 3, EC:1.4.3.21

Description

Amine oxidase, copper containing 3, also known as vascular adhesion protein (VAP-1) and HPAO is an enzyme that in humans is encoded by the AOC3 gene on chromosome 17. This protein is a member of the semicarbazide-sensitive amine oxidase (SSAO; aka primary amine oxidase) family of enzymes and is associated with many vascular diseases. It has semicarbazide-sensitive (SSAO) monoamine oxidase activity and may play a role in adipogenesis. Cell adhesion protein participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion.

KO Status

RenMab: F0

Drug Information

Launched drugs: 2
Drugs in clinical trials: 6
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Hydralazine hydrochloride/Isosorbide Dinitrate

AR-06

Approved

Arbor Pharmaceuticals

Heart Failure

Hydralazine hydrochloride

BPI-103

Approved

Novartis Pharma Ag

Heart Failure, Hypertension, Macular Degeneration

PXS-4728

PXS-4728, PXS-4728A, BI-1467335

Phase 2 Clinical

Pharmaxis

Renal Insufficiency, Non-alcoholic Fatty Liver Disease, Diabetic Retinopathy

PRX-167700

PRX-167700, PRX 167700H, PRO VAP-1 inh

Phase 2 Clinical

Cambridge Biotechnology

Pain, Osteoarthritis, Knee

Timolumab

SI-3106, BTT-1023

Phase 2 Clinical

Biotie

Arthritis, Rheumatoid, Cholangitis, Sclerosing, Psoriasis

ECC-0509

ECC-0509

Phase 1 Clinical

Non-alcoholic Fatty Liver Disease, Osteoarthritis

TERN-201

TERN-201

Phase 1 Clinical

Terns Pharmaceuticals Inc

Non-alcoholic Fatty Liver Disease

TT-01025

TT-01025-CL

Phase 1 Clinical

Yaojie Ankang (Nanjing) Technology Co Ltd

Non-alcoholic Fatty Liver Disease

UD-014

UD-014

Preclinical

Ube Industries Ltd

Non-alcoholic Fatty Liver Disease, Diabetic Nephropathies

Magnesium valproate/Hydralazine hydrochloride

Pending

Neolpharma

Uterine Cervical Neoplasms

References


Title

Authors

Source

Functional modulation of vascular adhesion protein-1 by a novel splice variant

Kaitaniemi S., Gron K., Elovaara H., Salmi M., Jalkanen S., Elima K.,

PLoS ONE 8:E54151-E54151(2013)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage

Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L., Nusbaum C.,

Nature 440:1045-1049(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes

Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.,

Biochem. J. 383:237-248(2004)

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry

Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.,

J. Proteome Res. 4:2070-2080(2005)

Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes

Bour S., Daviaud D., Gres S., Lefort C., Prevot D., Zorzano A., Wabitsch M., Saulnier-Blache J.-S., Valet P., Carpene C.,

Biochimie 89:916-925(2007)

The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase

Kaitaniemi S., Elovaara H., Groen K., Kidron H., Liukkonen J., Salminen T., Salmi M., Jalkanen S., Elima K.,

Cell. Mol. Life Sci. 66:2743-2757(2009)

Cloning and sequencing of a copper-containing, topaquinone-containing monoamine oxidase from human placenta

Zhang X., McIntire W.S.,

Gene 179:279-286(1996)

Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule

Smith D.J., Salmi M., Bono P., Hellman J., Leu T., Jalkanen S.,

J. Exp. Med. 188:17-27(1998)