RenLite RenLite® Mouse: Empower Bispecific or Multispecific Antibody Development Key Features 1. Complete human heavy chain variable domain combined with a common light chain substitution in situ 2. Fully human heavy chain antibody repertoire diversity IGH-V (>1%)IGH-V (<1%)IGH-DIGHJHeavy chain IGHV germline usage of naive RenLite™ mice Heavy chain IGHV germline usage of naive RenLite™ mice Heavy chain IGHD germline usage of naive RenLite™ mice Heavy chain IGHJ germline usage of naive RenLite™ mice 3. Human-like CDR3 features The median length of heavy chain CDR3 (14aa) from naive Renite™ mice is comparable to the average length of human CDR3. Human-like CDR3 features, such as increasing frequency of tyrosine usage, are observed in RenLite™ mouse heavy chain CDR3. 4. Robust immune response comparable to wild type mouse Validation Data 1. RenLite® mice show similar immune cell profiles to wild type mice 2. RenLite™ mice show overall normal B cell development with slight delay compared to wild type mice. Spleen B cell developmentBone marrow B cell develoment3. Serum immunoglobulin Isotype & IgG Subtype Analysis Serum concentrations of IgA, IgM and IgG subtypes of RenLite™ and wild type mice were measured by ELISA. Sera were equally diluted between two groups of mice. Learn more: RenMab™/RenLite® Technical Data Sheet Download brochure
